Born 6 Jun 1944.

Phillip Allen Sharpe is an #American #molecular #biologist, who shared the 1993 #NobelPrize for #Physiology or Medicine with Richard J. Roberts, for “their discoveries of #SplitGenes.”

#Genetic information in #DNA is transferred to the molecular chain of “messenger” #mRNA, composed of #exons (long sections which are required for #protein formation) and #introns (intervening sections that are inactive and not needed).

Working independently, Sharp and Roberts each showed how the the exons and introns of #RNA might be splittable from each other. This also predicted exons might be spliced together into a modified molecular chain—a #gene with the potential to form various different proteins. This spurred new research in #evolutionary #biology, and into the development of #cancer and other diseases.

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