English #biochemist, who shared the 1982 #NobelPrize for Physiology or #Medicine (with Sune K. Be…
English #biochemist, who shared the 1982 #NobelPrize for Physiology or #Medicine (with Sune K. Bergström and Bengt Ingemar Samuelsson of Sweden) for their isolation, identification, and analysis of #prostaglandins.
In 1971, Vane discovered how #aspirin's effect was to block the formation of the prostaglandins involved in #pain, #fever, and #inflammation. Further, a relatively small dose (75 mg/day) prevents blood clotting and lessen heart attacks, strokes and leg thromboses.
In 1976, he discovered #Prostacyclin , a blood-vessel dilating prostaglandin that inhibits #blood-clotting.
His discoveries led to the Ace inhibitors, a new class of drugs giving life-saving benefits to patients with pulmonary #hypertension, and new treatments for #heart disease.
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