#American #biochemist whose contributions in elucidating the chemical #structure of #antibodies w…

#American #biochemist whose contributions in elucidating the chemical #structure of #antibodies won him (with Rodney Porter) the #NobelPrize for #Medicine or Physiology in 1972.

Edelman studied the structure of #human #immunoglobulin. He first split this large molecule into smaller portions, by reducing and splitting the disulfide bonds.

Edelman proposed that the molecule contained two kinds of #polypeptide chains: light and heavy. From such studies, Porter proposed a structure for the antibody #ImmunoglobulinG (IgG) in 1962.

Edelman aimed to work out the complete #amino-acid #sequence of IgG. As it contained 1330 amino acids it was by far the largest protein then attempted. By 1969 he announced the complete sequence.

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