English #biochemist, who shared the 1982 #NobelPrize for Physiology or Medicine (with Sune K. Ber…

English #biochemist, who shared the 1982 #NobelPrize for Physiology or Medicine (with Sune K. Bergström and Bengt Ingemar Samuelsson of Sweden) for their isolation, identification, and analysis of #prostaglandins.

In 1971, Vane discovered how #aspirin's effect was to block the formation of the prostaglandins involved in #pain, #fever, and #inflammation. Further, a relatively small dose (75 mg/day) prevents blood clotting and lessen #heartattacks, #strokes and leg #thromboses.

In 1976, he discovered #prostacyclin, a blood-vessel dilating prostaglandin that inhibits blood-clotting.

His discoveries led to the Ace inhibitors, a new class of drugs giving life-saving benefits to patients with pulmonary #hypertension, and new treatments for #heart disease.