Charles Herbert Best was an American-Canadian physiologist who, while 22 years old, assisted Dr F…

Charles Herbert Best was an American-Canadian physiologist who, while 22 years old, assisted Dr Frederick Banting, in Toronto, Canada, with the discovery (1921) of a pancreatic extract - the hormone insulin - that could control diabetes in the dogs they used as test subjects. This led to human diabetics being treated with insulin.

Banting (with J.J.R. Macleod) received the 1923 Nobel Prize for Physiology or Medicine.

Best was not nominated because he did not receive his medical degree until 1925. However, Banting recognized Best's role by later voluntarily sharing the prize money with him.

Best also discovered the vitamin choline and the enzyme histaminase.

He was the first to introduce anticoagulants in treatment of thrombosis (blood clots).

Best was born in Maine, U.S.A., but for his university studies he moved to Canada, where he remained.

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