Born 17 Apr 1925.

#American #geneticist who demonstrated the #colinearity of #gene and #protein structures.

In the 1960s, Yanofsky began work on the structure of proteins and genes responsible for #tryptophan biosynthesis.

He used the #expression and #regulation of these proteins as tools to dissect the inner workings of the cell's #genetic apparatus. This work on the nature of #mutations that prevent tryptophan #biosynthesis produced some of his most significant discoveries.

His remarkable exploitation of the E. coli tryptophan operon to work out the biochemical pathway of the synthesis of an #aminoacid and to elucidate fundamental aspects of #transcription and #translation, such as #missense #suppression and #polarity, are historic achievements.

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