William Howard Stein was an #American #biochemist who (with Stanford Moore and Christian B. Anfin…
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William Howard Stein was an #American #biochemist who (with Stanford Moore and Christian B. Anfinsen) was a cowinner of the #NobelPrize for #Chemistry in 1972 for their studies of the #pancreatic #enzyme #ribonuclease.
Stein, with Moore, investigated the connection between its chemical #structure and the #catalytic activity of the active centre of the ribonuclease molecule.
Between 1949 and 1963, they developed methods for the analysis of #aminoacids and #peptides obtained from #proteins, determined the structure of ribonuclease, and it catalyzes the #digestion of #food.
By 1972, they had also worked out the complete sequence of #deoxyribonuclease, a molecule twice as complex as ribonuclease.
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