Born 13 Apr 1941.

Michael Stuart Brown is an #American molecular #geneticist who, with Joseph L. Goldstein, was awarded the 1985 #NobelPrize for Physiology or Medicine for their elucidation of a key link in the #metabolism of #cholesterol in the human body.

They compared cells of normal persons with those of persons having familial #hypercholesterolemia, (who #inherit a tendency to abnormally high blood cholesterol levels and circulatory ailments). They traced a #genetic defect that resulted in their being deficient in cell #receptors for #LDL (low-density #lipoproteins - the primary cholesterol carrying particles). These cell receptors draw the LDL particles into the cells as a prelude to breaking them down, and thus remove them from the bloodstream.

www.masterdoctorclinic.com